14 Comments
Feb 4, 2023Liked by Suman Manchireddy

Very interesting. I look forward to reading how this has helped you as well.

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Hi Susan, thank you for your comments. I try to limit calories 2 days a week as I have written on chapter 7.

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May 8, 2022Liked by Suman Manchireddy

Good morning, like you, I survived a hear attack + cardiac arrest at a young age (41). Also, like you, I wrote about my experience for awhile. My intent was to raise awareness and help others. I don't think many people ever found my blog (www.heartgeek.com), but I found writing about the experience to be very therapeutic. 15-years later, I am still very active and healthy but I do find my attention to diet has slipped. I just found your newsletter and look forward to learning more about your experience and the benefits of fasting. It appears that we may also be neighbors! Keep up the great work and stay healthy.

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Thank you Paul. I am glad you are doing great. Unfortunately heart disease is the number one killer all around the world, some ethnicities have much higher rates than the other. My sincere effort just like you bring awareness and do work on prevention of disease.

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May 5, 2022Liked by Suman Manchireddy

Good explanation of the metabolic mechanisms of fasting. Really love your graphs. Nice charting of the hand-off of glucose provision from food to glycogenolysis to gluconeogenesis. Also, your graph shows that protein utilization is very flat during fasting - no increase. This is important because so many people fixate on concerns about muscle loss with fasting. Do you have a source for these figures or did you compile them yourself?

Finally I appreciate your statement about the difficulty of fasting for more than three days. I have found I can often get to three days but my record is only 4 and half days, and that last day and half achieved only with great effort.

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Hi Tim, Thank you for your comment.

Great, you are able to do a 3 day fast, thats when most of autophagy happens.

Yes, the graph was easy to understand and gives clear description of how substrates are utilized. I had extensive literature search for this post. I sourced the graph from the paper from Nutrients 2022.

Effects of Intermittent Fasting on Cardiometabolic Health: An Energy Metabolism Perspective

https://www.mdpi.com/2072-6643/14/3/489/htm

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May 4, 2022Liked by Suman Manchireddy

Excellent post. Thank you for mining the latest research and presenting it in layman's terms with actionable advice. Please keep them coming!

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Thanks Karen for your kind words.

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May 4, 2022Liked by Suman Manchireddy

Mostly we do things without knowing the reason like fasting.By reading this article now. we are sure why we need to do fasting.Thanks to my brother. who is trying to educate the unknown facts of health.

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Thank you, Preethi.

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May 4, 2022Liked by Suman Manchireddy

The word fasting will stimulate hunger in me , but no food for cancer or pre cancerous cells that is a good idea.

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May 4, 2022Liked by Suman Manchireddy

Very informative and well-written!

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Such a detailed analysis - gonna start with once a day low calorie count for healthy living!

Keep positing and sharing :)

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Thank you.

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